Drug interactions
Cannabis interacts with the same liver enzymes (CYP3A4, CYP2C9) that metabolize many medications. Talk to a doctor before combining with:
- Blood thinners (warfarin) — cannabis can increase blood levels, raising bleed risk.
- Antidepressants (SSRIs, MAOIs) — generally safe but can amplify some side effects.
- Sedatives, benzodiazepines, opioids — additive sedation, respiratory depression.
- Antiseizure medications — variable; some interact strongly.
- Statins — cannabis can increase blood levels.
- Immunosuppressants — interactions possible, talk to oncologist / specialist.
Rule of thumb: if you take a daily prescription medication, check with your prescriber before starting regular cannabis use.
Pregnancy + breastfeeding
- Don't. Cannabinoids cross the placenta and pass into breast milk.
- Linked to lower birth weight, developmental issues. The data isn't perfect but the precautionary stance is universal.
Driving
- Don't drive impaired. Same legal standard as alcohol — DUI charges apply.
- Effects on driving: slower reaction time, impaired distance judgment, time distortion.
- Wait at least 4 hours after smoking/vaping, 8+ hours after an edible.
Operating machinery, work hazards
- Same rule as driving. Don't.
- If you operate forklifts, drive a truck, work in healthcare or aviation — your employer drug-tests, and a positive ends careers in those industries.
Mental health
- Schizophrenia / psychosis history (personal or family): cannabis can trigger or worsen psychotic episodes, especially high-THC products. Avoid or use only under medical supervision.
- Heavy daily use in adolescence (under 25): linked to increased risk of psychotic disorders, lower IQ, decreased motivation. Brain still developing.
- Anxiety disorders: moderate-THC products help some, worsen others. Start very low; CBD-leaning may be better than THC-dominant.
Cannabis Hyperemesis Syndrome (CHS)
Rare condition in heavy chronic users — cyclic vomiting + abdominal pain that only stops when cannabis stops. Hot showers temporarily relieve. If a customer mentions cyclic vomiting + heavy daily use, refer to ER and recommend cessation.